It depends on your state's eligibility rules. In every state, an employee who quits a job voluntarily, without good cause, won't be allowed to collect unemployment. But each state has its own definition of good cause for quitting. In some states, employees may collect unemployment only if they quit for reasons related to the job, such as intolerable working conditions or a medical condition caused or aggravated by the job. Other states allow employees to collect unemployment if they quit for compelling personal reasons, such as domestic violence or serious illness in the family. For more information, see Nolo's article Unemployment Benefits: What If You Quit?